HIV/HBV co-infection: Natural history (MACS)
•Liver-related mortality in a cohort of 5293 MSM (1984 /1987–2000)
•
Thio CL, et al. Lancet. 2002;360:1921−26
Viral status
Person years
HIV
HBsAg
Liver-related mortality (n)
Liver death
(1000 pers/yr)
p
31,366
–
–
0
0.0
1318
–
+
1
0.8
0.04
2065
+
–
35
1.7
<0.0001
1834
+
+
26
14.2
<0.0001
55,123
Overall
62
1.1
HBV/HIV coinfected patients were 19X more likely to die from liver disease than those infected with HBV alone (RR18.7, 3.1–766.1, p<0.001)