Chronic hepatitis B: Influence of HBV DNA
REVEAL Study: Cumulative incidence
of liver cirrhosis
All subjects (n=3582)
Years of
follow-up
Baseline HBV
DNA level, copies/mL
Log rank
test of trend
p<0.001
≥106 (n=602)
105–<106 (n=333)
104–<105 (n=628)
300–<104 (n=1,150)
<300
(n=869)
20
10
0
1
2
3
4
5
6
7
8
9
10
11
12
13
0
40
30
4.5%
5.9%
9.8%
23.5%
36.2%
14
Adapted from Iloeje UH, et al.
Gastroenterology 2006;130;678–86