Interferon treatment in HIV/HBV
co-infected patients
Pts
αIFN
(MU)
(MU)
Months
therapy
CD4
(cells/mm3)
HBV
DNA <6 log10 copies/mL
HBeAg
Clear.
McDonald 87
14
2.5–10
6
-
-
0
Marcellin 93
10
3–5
4–6
20–858
2
2
Wong 95
12
10
6
No AIDS
1
1
Zylberberg 96
25
6
6
480±234
9
2
Di Martino 02
26
5
6
331±207
7
3
Total
87
19 (26%)
8 (9%)
•HBeAg
seroreversion frequent. No HBsAg loss
McDonald, Hepatology 1987; 7(4):719-23.
Marcellin, Gut 1993;34(Suppl 2):S106. Wong, Gastroenterology 1995;108:165-171; Zylberberg,
Gastroenterol Clin Biol 1996;20:968−71. Di Martino, Gastroenterology
2002;123(6):1812-22.