Anti-HIV activity under telbivudine?
•45-year-old gentleman with
HIV/HBV co-infection
•HBV-DNA 662,000,000 copies/mL,
HBe-Ag+
•CD4 640 cells/µL, HIV-RNA 8,650
copies/mL
•In January 2008 the patient was
offered triple HAART with TDF/FTC/EFV or HBV dual therapy with
ADF/LdT; the patient commenced dual HBV therapy
•5 months later LdT was stopped
(HIV-RNA 127 copies/mL) and
HIV-RNA rebounded to 3903 copies/mL one month after LdT was stopped
HIV-RNA rebounded to 3903 copies/mL one month after LdT was stopped
•Rechallenge of LdT led to a
drop in HIV-RNA from 1074 to 177copies/mL after one week and 71 copies
after 2 weeks
Low E et al.,
CROI 2009, Abstract 813a