Initial in vitro studies on anti-HIV activity of
telbivudine and entecavir
in two HIV isolates
in two HIV isolates
•EC50 was
determined using concentrations of telbivudine ranging from 30.5 nM to 600 μM
•Entecavir (300 μM) and DMSO (600 μM) were used as controls
HIV isolate
Host
DMSO
EC50 (μM)
EC50 (μM)
Entecavir
EC50 (μM)
EC50 (μM)
Telbivudine
EC50 (μM)
EC50 (μM)
CNDO
HEK 293
>600
45.26
>600
MDRC4
HEK 293
>600
16.85
>600
CNDO Drug-sensitive reference virus derived from NL4-3 strain
of HIV-1.
MDRC4 Multidrug-resistant reference strain R268.
Avila et al.,
CROI 2009, Abstract 813b