News in hepatitis B
•Objective: To characterise
frequency and reasons for failure to control HBV replication during
treatment with tenofovir
•150/168 patients had an HBV-DNA
level <2000 IU/mL at the end of follow-up (median treatment duration was
31 months)
•18 patients had virological
failure whereby of these only 6 patients had adequate TDF levels; in these
4/5 showed a L217R polymorphism (HBV GTA2 polymorphism)
Lacombe K et
al.,CROI 2009;#100